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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-4
All Species:
15.15
Human Site:
Y145
Identified Species:
27.78
UniProt:
Q9H2Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H2Z4
NP_149416.1
354
36179
Y145
G
A
N
P
D
P
R
Y
S
S
I
S
R
F
M
Chimpanzee
Pan troglodytes
XP_525278
419
42955
Y210
G
A
N
P
D
P
R
Y
S
S
I
S
R
F
M
Rhesus Macaque
Macaca mulatta
XP_001093634
451
46942
Y242
G
A
N
P
D
P
R
Y
S
S
I
S
R
F
M
Dog
Lupus familis
XP_849082
233
24205
A58
L
A
P
L
H
A
A
A
A
A
A
A
A
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQM3
354
36207
Y148
G
A
N
T
D
P
R
Y
S
S
I
S
R
F
M
Rat
Rattus norvegicus
P23441
372
38536
G134
R
F
M
G
P
A
S
G
M
N
M
S
G
M
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
R119
E
R
P
R
Q
R
K
R
R
K
P
R
V
L
F
Frog
Xenopus laevis
P42587
196
22791
L21
L
I
H
D
G
W
L
L
L
R
A
S
N
T
P
Zebra Danio
Brachydanio rerio
Q90481
269
30288
S93
L
H
G
L
S
A
N
S
Q
D
T
S
A
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
T488
L
H
N
N
N
N
N
T
T
N
N
N
N
H
S
Honey Bee
Apis mellifera
XP_394578
395
41030
A165
R
S
H
H
P
W
Y
A
P
A
P
P
A
T
N
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
A124
D
P
R
F
A
A
A
A
A
L
L
P
C
S
I
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
R185
Q
V
Y
E
L
E
R
R
F
K
Q
Q
K
Y
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.2
77.1
61.2
N.A.
94.3
59.4
N.A.
N.A.
29.9
28.8
31
N.A.
24.3
37.9
31.6
38.9
Protein Similarity:
100
84.2
77.1
62.9
N.A.
94.6
66.4
N.A.
N.A.
42
38.4
42.9
N.A.
32
49.6
43.7
51.3
P-Site Identity:
100
100
100
6.6
N.A.
93.3
6.6
N.A.
N.A.
0
6.6
6.6
N.A.
6.6
0
0
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
20
N.A.
N.A.
6.6
13.3
6.6
N.A.
33.3
20
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
39
0
0
8
31
16
24
16
16
16
8
24
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
8
0
0
8
31
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
8
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
8
0
0
0
0
8
0
0
0
0
31
8
% F
% Gly:
31
0
8
8
8
0
0
8
0
0
0
0
8
0
8
% G
% His:
0
16
16
8
8
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
31
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
8
0
0
16
0
0
8
8
0
% K
% Leu:
31
0
0
16
8
0
8
8
8
8
8
0
0
8
8
% L
% Met:
0
0
8
0
0
0
0
0
8
0
8
0
0
8
31
% M
% Asn:
0
0
39
8
8
8
16
0
0
16
8
8
16
0
8
% N
% Pro:
0
8
16
24
16
31
0
0
8
0
16
16
0
8
8
% P
% Gln:
8
0
0
0
8
0
0
0
8
0
8
8
0
0
0
% Q
% Arg:
16
8
8
8
0
8
39
16
8
8
0
8
31
0
8
% R
% Ser:
0
8
0
0
8
0
8
8
31
31
0
54
0
8
16
% S
% Thr:
0
0
0
8
0
0
0
8
8
0
8
0
0
16
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
16
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
8
31
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _